SHS_300304 WELL CUUT 16042

Efficacy of Delayed Enhancement MRI-Guided Ablation vs Conventional Catheter Ablation of Atrial Fibrillation: The DECAAF II Study

This proposal is aiming at modifying and improving persistent AF management guidelines by evaluating targeting DE-MRI detected atrial fibrosis during AF ablation and its related effect on procedural outcome.

Inclusion Criteria:

Patients with persistent AF undergoing first AF ablation as per recent HRS consensus document. Persistent AF is defined by 7 days or more in AF as evidenced by either 1) rhythm strip or 2) written documentation.
Must have some proportion of atrial fibrosis (not limited to advanced stage fibrosis)
Able to understand and willing to sign the Informed Consent Form
Age ≥ 18 years

Exclusion Criteria:

Contraindication for DE-MRI with a full dose of Gadolinium-based contrast agent
Previous left atrial ablation or surgical procedure
Women currently pregnant
Mental or physical inability to take part in the study
Uncontrolled hypertension
Inability to be placed in MRI due to body mass
N/A
NCT02529319
Heart and Vascular, All Other
Arrhythmias
Darryl Wells, M.D.
University of Utah
xChristine Goetz
  • Swedish Medical Center