HVP_12-079-ischemia

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches

The purpose of the ISCHEMIA trial is to determine the best management strategy for higher-risk patients with stable ischemic heart disease. This is a multicenter randomized controlled trial with a target enrollment of ~5000 patients with at least moderate ischemia on stress imaging. Patients will be assigned at random to a routine invasive strategy (INV) with cardiac catheterization (cath) followed by revascularization plus optimal medical therapy (OMT) or to a conservative strategy (CON) of OMT, with cath and revascularization reserved for those who fail OMT.
Key Inclusion Criteria:

1. At least moderate ischemia on an ischemia test
2. Participant is willing to comply with all aspects of the protocol, including adherence to the assigned strategy, medical therapy and follow-up visits
3. Participant is willing to give written informed consent
4. Age ≥ 21 years

See clinicaltrials.gov for full details.
N/A
NCT01471522
Heart and Vascular
Coronary Artery Disease
Charles Cannan, M.D.
Gerald Leonard
  • Providence Portland Medical Center