A Randomized, Double-blind, Event-driven, Placebo-controlled, Multicenter Study of the effects of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects With Type 2 Diabetes Mellitus and Diabetic Nephropathy. The CREDENCE Trial

The goal of this study is to assess whether canagliflozin has a renal and vascular protective effect in reducing the progression of renal impairment relative to placebo in participants with type 2 diabetes mellitus (T2DM), Stage 2 or 3 chronic kidney disease (CKD) and macroalbuminuria, who are receiving standard of care including a maximum tolerated labeled daily dose of an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB).
Phase III
All Other
Diabetic Kidney Disease
Radica Alicic MD
Janssen Research & Development
Mary Bates
  • Spokane Research
  • Spokane Sacred Heart Medical Center