SHS_492326 GOLP CMER 15288

A Phase III Study of Pembrolizumab (MK-3475) vs. Chemotherapy in Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (KEYNOTE-177)

In this study, participants with MSI-H or dMMR advanced colorectal carcinoma will be randomly assigned to receive either pembrolizumab or the Investigator's choice of 1 of 6 standard of care (SOC) chemotherapy regimens for the treatment of advanced colorectal carcinoma. The primary study hypothesis is that pembrolizumab will prolong progression-free survival (PFS) compared to current SOC chemotherapy.

Select Inclusion Criteria:

•Locally confirmed dMMR or MSI-H stage IV colorectal carcinoma
•Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
•Life expectancy of at least 3 months
•Measurable disease
•Adequate organ function

Select Exclusion Criteria:

•Has received prior systemic therapy for Stage IV colorectal cancer. May have received prior adjuvant chemotherapy for colorectal cancer as long as it was completed at least 6 months prior to randomization on this study
•Active autoimmune disease that has required systemic treatment in past 2 years
•Diagnosis of immunodeficiency or receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to randomization on this study
•Radiation therapy within 4 weeks prior to randomization on this study and not recovered to baseline from adverse events due to radiation therapy
•Known active central nervous system (CNS) metastases and/or carcinomatous meningitis
•Major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to randomization on this study
•Has received prior therapy with an immune checkpoint inhibitor
•Another malignancy that is progressing or requires active treatment with the exception of non-melanomatous skin cancer that has undergone potentially curative therapy and in situ cervical carcinoma
•Received a live vaccine within 30 days of planned start of study medication
•Known history of Human Immunodeficiency Virus (HIV), Hepatitis B or C
•Known history of, or any evidence of interstitial lung disease or active, non-infectious pneumonitis
•Active infection requiring systemic therapy
•Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study
•Pregnant, breastfeeding, or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 180 days after the last dose of SOC or 120 days after the last dose of pembrolizumab
Phase III
Philip Gold, M.D.
Erik Bailey
  • Swedish Medical Center