PCRC_E7208

A Randomized Phase II Study of Irinotecan and Cetuximab With or Without the Anti-Angiogenic Antibody, Ramucirumab (IMC-1121B), in Advanced, K-ras Wild-Type Colorectal Cancer Following Progression on Bevacizumab-Containing Chemotherapy

This randomized phase II trial is studying the side effects and how well giving cetuximab and irinotecan hydrochloride with or without ramucirumab work in treating patients with advanced colorectal cancer with progressive disease after treatment with bevacizumab-containing chemotherapy.

Criteria
DISEASE CHARACTERISTICS:

Histologically confirmed adenocarcinoma of the colon or rectum, including:
* Advanced disease
* Histologic variants of adenocarcinoma allowed
* K-ras wild type based on either primary or metastatic tumor
** No mutated type
* Measurable disease
* Must have received prior first-line therapy comprising oxaliplatin-based fluoropyrimidine-containing chemotherapy and bevacizumab for metastatic colorectal cancer
* No more than 42 days since confirmed disease progression
* No brain or CNS metastases
Phase II
NCT01079780
Cancer, All Other
Gastrointestinal
Alison Conlin, M.D.
ECOG (Eastern Cooperative Oncology Group)
Yue-Yun To

The Pacific Cancer Research Consortium clinical trials are offered at multiple locations throughout Oregon, Washington, Alaska, California, and Idaho. To find a location near you, please contact the Patient Engagement Center at 844-552-2734.