ONC_ANBL1232

Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-high-risk Neuroblastoma

This phase III trial studies how well response and biology-based risk factor-guided therapy works in treating younger patients with non-high risk neuroblastoma. Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Measuring biomarkers in tumor cells may help plan when effective treatment is necessary and what the best treatment is. Response and biology-based risk factor-guided therapy may be effective in treating patients with non-high risk neuroblastoma and may help to avoid some of the risks and side effects related to standard treatment.
Eligibility:
Age: up to 17 months
•Patients must be:

◦< 12 months (< 365 days) of age at diagnosis with INRG stage L1; or
◦< 18 months (< 547 days) of age at diagnosis with INRG stage L2 or stage Ms neuroblastoma/ganglioneuroblastoma
•Enrollment on ANBL00B1 is required for all newly diagnosed patients
•Patients must have newly diagnosed v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) non-amplified neuroblastoma (International Classification of Diseases for Oncology [ICD-O] morphology 9500/3) or MYCN non-amplified ganglioneuroblastoma verified by histology.
Phase III
NCT02176967
Cancer
Pediatric
Brenda Wittman, M.D.
COG (Childrens Oncology Group)
Katie Jones
  • Alaska Research
  • Providence Alaska Medical Center