Featured research studies

Unmasking PD-1 Resistance by Next-Generation Sequencing

Monoclonal antibodies that inhibit the programmed death 1 (PD-1)–programmed death ligand 1 (PD-L1) pathway are clinically active against a broad range of tumors; however, even the most susceptible tumors (e.g., melanoma) respond less than half the time because of innate resistance. In this issue of the Journal, Zaretsky et al.1 describe the use of whole-exome sequencing to identify mechanisms of acquired immune resistance in tumors from patients with melanoma who had a relapse after more than 6 months of tumor response to treatment with pembrolizumab. Tumor regression after PD-1–PD-L1 blockade is presumed to be mediated by the activation of tumor-infiltrating...
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The Carotid Artery As a Preferred Alternative Access Route For Transcatheter Aortic Valve Replacement.

Kirker EB, Hodson RW, Spinelli KJ, Korngold EC. (2017)
Recent clinical trials underscore the benefits of transcatheter aortic valve replacement compared to surgical valve replacement. With more heart surgery teams adopting this technique for a wider patient population, there is an increasing need for safe alternative access routes in patients where femoral access is not an option. Here we report procedural, in-hospital and 30-day outcomes that support use of the carotid artery as a preferred alternative access route.”
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Under pressure: when to stick your neck out?

Abraham J, Lewis RS, Wang L, Spinelli KJ, Remick J, Paulson J, Chappell J. (2017)
In this Letter to the Editor, we describe our experience delivering the CardioMEMS pressure sensor through the internal jugular vein. This is the first report of successful use of this access route in a small cohort of patients.
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Surgical occlusion of the left atrial appendage and thromboembolic complications in left ventricular assist device patients.

Lewis RS, Wang L, Spinelli KJ, Ott GY, Abraham J. (2017)
Patients who have a continuous-flow left ventricle heart pump have a high risk of complications such as stroke or thrombosis. This is the first report of a simple surgical procedure that can be done during implantation of the heart pump to lower the risk of thrombosis and related complications, up to three years after surgery.
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A randomized, double-blind, phase 2 trial of platinum therapy plus etoposide with or without concurrent vandetanib (ZD6474) in patients with previously untreated extensive-stage small cell lung cancer: Hoosier Cancer Research Network LUN06-113

Rachel Sanborn, M.D., Co-Director, Thoracic Oncology Program, Phase I Trials Program at the Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, published an important phase 2 trial of a new combination drug therapy in patients with extensive small cell lung cancer. Featured in the Cancer journal.
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GBM-associated mutations and altered protein expression are more common in young patients.

Glioblastoma research from Santosh Kesari, M.D., Department of Translational Neuro-Oncology and Neurotherapeutics, Pacific Neuroscience Institute and John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA. Featured in the Oncotarget journal.
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Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

David Hoon, Ph.D., Professor, Director Molecular Oncology & Sequencing Center, John Wayne Cancer Institute, Saint John’s Health Center Providence, Santa Monica, CA, served on an expert panel discussing "Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?"
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Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors

In June 2016, Dr. Delphine Lee’s team at the Dirks/Dougherty Laboratory for Cancer Research, Department of Translational Immunology, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, published a scientific report on the microbiome in breast cancer survivors in the prestigious Nature journal.
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Patients with Low National Institutes of Health Stroke Scale Scores Have Longer Door-to-Needle Times: Analysis of a Telestroke Network

Investigator-initiated retrospective registry study from Providence Brain & Spine Institute
Bhatt A, Lesko A, Lucas L, Kansara A, Baraban E.
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Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients

Providence St Vincent Medical Center Surgeons involved in a large multi-center heart valve trial
Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK, Thourani VH, Tuzcu EM, Miller DC, Herrmann HC, Doshi D, Cohen DJ, Pichard AD, Kapadia S, Dewey T, Babaliaros V, Szeto WY, Williams MR, Kereiakes D, Zajarias A, Greason KL, Whisenant BK, Hodson RW, Moses JW, Trento A, Brown DL, Fearon WF, Pibarot P, Hahn RT, Jaber WA, Anderson WN, Alu MC, Webb JG; PARTNER 2 Investigators.
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Safety and efficacy of daclizumab in relapsing-remitting multiple sclerosis: 3-year results from the SELECTED open-label extension study

Multi-center sponsored Multiple Sclerosis trial
Gold R, Radue EW, Giovannoni G, Selmaj K, Havrdova E, Stefoski D, Sprenger T, Montalban X, Cohan S, Umans K, Greenberg SJ, Ozen G, Elkins J.
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The potential of molecular diagnostics and serum procalcitonin levels to change the antibiotic management of community-acquired pneumonia

Providence Portland Medical Center Gilbert D, Gelfer G, Wang L, Myers J, Bajema K, Johnston M, Leggett J. Diagn Microbiol Infect Dis. 2016 Sep;86(1):102-7.
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A method to estimate the mean lifetime survival increase of statin therapy

System wide cardiovascular team Chang SC, Wang M, Beckerman JG, Sanz M, Gluckman TJ, Grunkemeier GL.
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Surveillance of guideline practices for duodenoscope and linear echoendoscope reprocessing in a large healthcare system

System wide digestive health team Brandabur JJ, Leggett JE, Wang L, Bartles RL, Baxter L, Diaz GA, Grunkemeier GL, Hove S, Oethinger M.
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Unmasking PD-1 Resistance by Next-Generation Sequencing

Editorial by Carlo B. Bifulco, M.D., and Walter J. Urba, M.D., Ph.D. , published on September 1, 2016
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