A Longitudinal Assessment of Tumor Evolution in Patients with Brain Cancer

This is a prospective, multi-center, open-label, randomized, multi-arm exploratory study to assess the safety and tolerability of nivolumab and nivolumab in combination with ipilimumab prior to radiation therapy (neoadjuvant setting) and to collect biological specimens before, during, and after treatments to identify determinants of response and safety. Parallel assessment of standard radiation and temozolomide on tumor microenvironment will provide a comparison to understanding tumor stratification. The study is being submitted as part of the P01 grant application for NIH funding.
Santosh Kesari, M.D.
John Wayne Cancer Institute
Shelly Trujillo
  • John Wayne Cancer Institute (JWCI)
  • Providence St. Johns Health Center (PSJHC)