ONC_AAML1531

Risk-Stratified Therapy for Acute Myeloid Leukemia in Down Syndrome

This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Response-based chemotherapy separates patients into different risk groups and treats them according to how they respond to the first course of treatment (Induction I). Response-based treatment may be effective in treating acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome while reducing the side effects.
Phase III
NCT02521493
Cancer
Pediatric
Brenda Wittman, M.D.
COG (Childrens Oncology Group)
Brittany Ledall
  • Alaska Research
  • Providence Alaska Medical Center